I don't know what victory condition you have it set on, but if it is unification, then there will be a date for a unification vote. You can find out what your standing is in the polls in the regional comparison pop-up. If it is set on total, then you just have to conquer everyone.
Also, it can be inconvenient to be kicked out of the WM, but it does not always mean defeat. Try and make your region as self sufficient as possible in every resource. The WM does not automatically boycott you in every resource, but if it does then you will be more ready to handle it. Self sufficiency also usually helps keep your economy stable. I am on the world map of a campaign I started as Dallas in the SW United States. I was expelled fom the WM early in the first scenario and never rejoined. So it can be done. Good hunting!